I remember reading somewhere along the medication instructions to drink water before dosing. Also, somewhere it said optimally to start with a dry mouth.
However, I’ve found that after placing Suboxone Film under my tongue, it takes quite a while for my mouth to fill up with saliva.
Rather dry, almost as if it was dissolving into the air, making contact with blank empty space instead.
What are some ways to improve the absorption process?
Perhaps the acidity from drinking coffee might adversely affect this somehow. I also tend to brush my teeth a couple hours before, followed by swishing with warm water.
My mouth will just be so dry. What are some ways to increase the saliva flow. Would it be possible to start with some liquids already in your mouth? Thanks!
Dry Mouth / Low Pools of Saliva on Suboxone Film
Re: Dry Mouth / Low Pools of Saliva on Suboxone Film
Actually a dry mouth INCREASES absorption. Bunivail got 50% absorption by holding the buprenorphine against the inner cheek, out of the pool of saliva. Suboxone gets 30%. Zubsolv gets 40% by creating a high local concentration of buprenorphine and changing the pH in that spot slightly.
Absorption is driven by diffusion -- a process of a substance moving from a high concentration to a lower concentration. The more saliva, the more dilution -- which reduces absorption.
Realize it does not need to be under the tongue. Again, Bunivail got the best absorption by putting against the inner cheek. I think that the best way to absorb the heck out of a strip is to put it ON your tongue and smear it against the inner cheek, then avoid drinking for 30 minutes and just forget about it. That will create a very high dose of buprenorphine in a small area that pushes it, very strongly, into tissue. The veins under the tongue are miles away from the surface, microscopically... and have nothing to do with absorption.. which is done by superficial capillaries. Realize too that the walls of those veins are much, much thicker than walls of capillaries. Cheers!
Absorption is driven by diffusion -- a process of a substance moving from a high concentration to a lower concentration. The more saliva, the more dilution -- which reduces absorption.
Realize it does not need to be under the tongue. Again, Bunivail got the best absorption by putting against the inner cheek. I think that the best way to absorb the heck out of a strip is to put it ON your tongue and smear it against the inner cheek, then avoid drinking for 30 minutes and just forget about it. That will create a very high dose of buprenorphine in a small area that pushes it, very strongly, into tissue. The veins under the tongue are miles away from the surface, microscopically... and have nothing to do with absorption.. which is done by superficial capillaries. Realize too that the walls of those veins are much, much thicker than walls of capillaries. Cheers!
- A-3D-model-of-the-oral-mucosa-The-oral-mucosa-is-divided-into-a-non-vascularized.jpg (22.28 KiB) Viewed 622 times
Re: Dry Mouth / Low Pools of Saliva on Suboxone Film
My mouth is so dry after administering Suboxone Film.
I’ll place it under my tongue, on the left or right side.
In front of a mirror, with mouth open.
Sometimes I’ll watch it dissolve while keeping my mouth wide open, in front of a mirror.
Otherwise, after placing the film strip under the tongue, I’ll close my mouth. However, there doesn’t seem to be any saliva production for at least 5-10 minutes!
Which is important, especially because I know you said that Buprenorphine is water-soluble. Only when turned into a liquid does it become active.
Without saliva, first the Suboxone film comes into contact with oxygen or pockets of air bubbles.
My tongue standing up straight, tip making contact with the roof of my mouth…Until yes, eventually the saliva will naturally get reproduced.
What are some ways to increase saliva production initially?
Which should help with the absorption of Suboxone Film
I’ll place it under my tongue, on the left or right side.
In front of a mirror, with mouth open.
Sometimes I’ll watch it dissolve while keeping my mouth wide open, in front of a mirror.
Otherwise, after placing the film strip under the tongue, I’ll close my mouth. However, there doesn’t seem to be any saliva production for at least 5-10 minutes!
Which is important, especially because I know you said that Buprenorphine is water-soluble. Only when turned into a liquid does it become active.
Without saliva, first the Suboxone film comes into contact with oxygen or pockets of air bubbles.
My tongue standing up straight, tip making contact with the roof of my mouth…Until yes, eventually the saliva will naturally get reproduced.
What are some ways to increase saliva production initially?
Which should help with the absorption of Suboxone Film
Re: Dry Mouth / Low Pools of Saliva on Suboxone Film
Maybe you didnt see what Doc wrote above but....Your lucky. A dry month is exactly what you want . Reread his post . Drier the better. A watery month only thins out the dose....Razor64...