Authors: van der Vijver RJ, van Laarhoven CJ, de Man BM, Lomme RM, Hendriks T
The authors examined the potential of the cyclooxygenase 2 (COX-2) inhibitor carprofen to reproducibly induce anastomotic leakage. In experiment 1, an anastomosis was constructed in both ileum and colon of 20 rats, and they were given carprofen (5 mg/kg subcutaneously every 24 hours) or buprenorphine (0.02 mg/kg subcutaneously every 12 hours). In another 20 rats an anastomosis was constructed in either ileum or colon, and all received carprofen (experiment 2). Animals were sacrificed after 3 days. In experiment 1, the ileal dehiscence rate was 60% in the carprofen group and 0% in the buprenorphine group (P = .0108). Colonic anastomoses in both groups remained patent. In experiment 2, the anastomo...Read more...
Source: MedWorm Query: BuprenorphineMedWorm.com provides a medical RSS filtering service. Data from over 6000 medical RSS feeds is collected and output via different categories. This feed contains the latest headlines from the user generated query: Buprenorphine